Multivalent breast cancer vaccine

摘要

Compositions and methods for immunization against human breast cancer are disclosed. In one embodiment the multivalent antigenic composition is provided comprising immunogenic polypeptides selected from the group consisting of human α-lactalbumin, αS1 casein, β-casein and κ-casein.

主权项

1. A method of preventing or treating breast cancer expressing human α-lactalbumin, human αS1 casein, human β-casein or human κ-casein in a non-lactating human female of a non-child bearing age in whom the genes encoding human α-lactalbumin, human αS1 casein, human β-casein and human κ-casein are not expressed by normal breast tissue, said method comprising administering to said non-lactating human female a multivalent antigenic composition comprising:
(i) human α-lactalbumin or a polypeptide comprising a 15 amino acid fragment thereof; (ii) human αS1 casein or a polypeptide comprising a 15 amino acid fragment thereof; (iii) human β-casein or a polypeptide comprising a 15 amino acid fragment thereof; and (iv) of human κ-casein or a polypeptide comprising a 15 amino acid fragment thereof,wherein the multivalent antigenic composition is administered in an amount effective to elicit a T-cell-mediated anti-tumor immune response against said breast cancer.