| 发明名称 | Leishmania-based carrier for vaccine delivery | ||
| 摘要 | The present invention provides a composition for delivering a protein vaccination candidate to a mammalian subject having a Leishmania transfected for expressing a cDNA sequence for encoding the protein vaccination candidate, and the Leishmania containing a photosensitizer. | ||
| 申请公布号 | US9327017(B2) | 申请公布日期 | 2016.05.03 |
| 申请号 | US201213468930 | 申请日期 | 2012.05.10 |
| 申请人 | Rosalind Franklin University of Medicine and Science | 发明人 | Chang Kwang-Poo;Dutta Sujoy |
| 分类号 | A61K39/00;A61K39/008;C12N1/10;A61K41/00 | 主分类号 | A61K39/00 |
| 代理机构 | Nixon Peabody LLP | 代理人 | Fuchs Joseph A.;Nixon Peabody LLP |
| 主权项 | 1. A composition comprising: a non-porphyric Leishmania transfected for expressing a cDNA sequence for encoding a protein vaccination candidate, the Leishmania containing a silicon-phthalocyanine or zinc-phthalocyanine photosensitizer; and an isolated mammalian antigen presenting cell having an endocytic compartment, a mitochondrion, a plasma membrane, the non-porphric Leishmania positioned in the cell, and a MHC Class I epitope containing a fragment of the protein vaccination candidate on an outer surface of the plasma membrane. | ||
| 地址 | North Chicago IL US | ||