| 发明名称 | Immunotherapy with binding agents | ||
| 摘要 | Binding agents that modulate the immune response are disclosed. The binding agents may include soluble receptors, polypeptides, and/or antibodies. Also disclosed are methods of using the binding agents for the treatment of diseases such as cancer. | ||
| 申请公布号 | US9327014(B2) | 申请公布日期 | 2016.05.03 |
| 申请号 | US201314096510 | 申请日期 | 2013.12.04 |
| 申请人 | ONCOMED PHARMACEUTICALS, INC. | 发明人 | Gurney Austin L.;Axelrod Fumiko Takada |
| 分类号 | A61K38/17;A61K38/19;C07K14/705 | 主分类号 | A61K38/17 |
| 代理机构 | Sterne, Kessler, Goldstein & Fox PLLC | 代理人 | Sterne, Kessler, Goldstein & Fox PLLC |
| 主权项 | 1. An isolated polypeptide comprising a poliovirus receptor (PVR) variant, wherein the PVR variant comprises one or more amino acid substitutions as compared to wild-type PVR (SEQ ID NO:1), wherein the substitutions comprise substitutions in one or more amino acids corresponding to amino acids 65, 67, 72, 74, 81, 82, 84, and 85 of wild-type PVR (SEQ ID NO:1), and wherein the PVR variant specifically binds the extracellular domain of human TIGIT and does not bind the extracellular domain of human CD226. | ||
| 地址 | Redwood City CA US | ||