Combination pharmaceuticals and methods thereof using proteinacious channels as treatments for medical conditions

摘要

Methods and combination pharmaceuticals for treating bronchospastic medical conditions by utilizing the electrophysiology of proteinacious channels in lipid membranes of mammalian cells. The combination pharmaceuticals include at least one β-adrenergic receptor agonist, and at least one composition adapted to effect the electrophysiology of Kv7 potassium channels of a lipid membrane of an airway smooth muscle cell. The pharmaceutical may be administered to a living body in a therapeutic amount sufficient to activate the Kv7 potassium channels of an airway smooth muscle cell.

主权项

1. A combination pharmaceutical comprising:
at least one β-adrenergic receptor agonist, wherein sustained or repetitive exposure by a subject to the β-adrenergic receptor agonist induces receptor desensitization in the subject; and at least one composition that activates Kv7 potassium channels of a lipid membrane of an airway smooth muscle cell; wherein the combination of the β-adrenergic receptor agonist and the composition mitigates the effects of the receptor desensitization induced by the β-adrenergic receptor agonist.