发明名称 |
NON-HUMAN ANIMALS HAVING A HUMANIZED SIGNAL-REGULATORY PROTEIN GENE |
摘要 |
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPa gene. Genetically modified mice are described, including mice that express a human or humanized SIRPa protein from an endogenous SIRPa locus. |
申请公布号 |
PH12016500342(A1) |
申请公布日期 |
2016.05.02 |
申请号 |
PH12016500342 |
申请日期 |
2016.02.19 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
MURPHY, ANDREW J.;THURSTON, O. GAVIN;VARGHESE, BINDU;GURER, CAGAN |
分类号 |
A01K67/027;C07K14/705;C12N15/90 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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