发明名称 |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
摘要 |
Provided are crystalline and amorphous forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide (formula 1). Further provided are intermediates useful in the preparation of the compounds. The compounds are JNK 1 and JNK2 inhibitors. The compounds may be useful in the treatment or prevention of interstitial pulmonary fibrosis, systemic sclerosis, scleroderma, chronic allograft nephropathy, antibody mediated rejection, lupus, liver fibrotic disorders, diabetes or metabolic syndromes leading to liver fibrotic disorders. |
申请公布号 |
NZ629885(A) |
申请公布日期 |
2016.04.29 |
申请号 |
NZ20140629885 |
申请日期 |
2014.09.03 |
申请人 |
SIGNAL PHARMACEUTICALS LLC |
发明人 |
HILGRAF ROBERT;YONG KELVIN HIN-YEONG;MUSLEHIDDINOGLU JALE;KOTHARE MOHIT ATUL;ZOU NANFEI;LI YING;BOERSEN NATHAN ANDREW;HUANG LIANFENG;BEAUCHAMPS MARIE GEORGES;MAN HON-WAH;FERRETTI ANTONIO CHRISTIAN;XU JEAN;NAGY MARK A.;ZOU DAOZHONG |
分类号 |
C07D239/48;A61K31/505;C07D239/30;C07D239/42 |
主分类号 |
C07D239/48 |
代理机构 |
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代理人 |
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地址 |
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