| 摘要 |
The invention disclosed in this document is related to the field of processes to produce certain 2-(pyridine-3-yl)thiazoles as intermediates for the synthesis of pesticidal thiazole amides. Compounds (I) and (lla) are reacted to produce compound (lib). Compounds (lla) and (llb) can be in the form of a salt or free base. The reaction is conducted in the presence of a base such as tnethylamine, when compound (lla) is a salt, and the reaction is conducted in a polar protic solvent. Compounds (lib) and (llc) are reacted to produce compound (III), in a polar solvent such as an ether or an alcohol. Compound (III) is cyclized using a dehydrating agent. Examples of such dehydrating agents include, but are not limited to, POCI3, H2S04, SOCI2, P205, polyphosphoric acid, p-toluene sulfonic acid, and trifluoroacetic anhydride. |
