| 发明名称 |
METHOD FOR SUPPRESSING TOLERANCE TO AN OPIOID-TYPE ANALGESIC |
| 摘要 |
The present invention relates to a method for suppressing tolerance to an opioid-type analgesic, such as morphine, by administering an effective amount of a compound of formula (IIIB) or (IIIC)or a pharmaceutically acceptable salt thereof, as well as to the use of the compound (IIIB) or (IIIC) having an antagonistic activity on an adenosine Areceptor, or a pharmaceutically acceptable salt thereof for the manufacture of a suppressant of the opioid-type analgesic tolerance. |
| 申请公布号 |
EA022994(B1) |
申请公布日期 |
2016.04.29 |
| 申请号 |
EA20100071395 |
申请日期 |
2009.05.29 |
| 申请人 |
KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
OUCHI JUN;KUNORI SHUNJI;KOJIMA YOZO;SHINODA KATSUMI;SASAKI KATSUTOSHI;SHIRAKURA SHIRO |
| 分类号 |
A61K45/00;A61K31/343;A61K31/427;A61K31/4439;A61K31/506;A61K31/519;A61K31/52;A61K31/522;A61P25/04;A61P43/00;C07D417/14;C07D473/06;C07D473/34;C07D487/04;C07D487/14;C07D495/04 |
主分类号 |
A61K45/00 |
| 代理机构 |
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代理人 |
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