| 摘要 |
Provided are sodium ibuprofen pharmaceutical compositions. In an embodiment a composition comprises a core, said core comprising sodium ibuprofen dihydrate and an excipient mixture comprising (a) at least one binder selected from saccharose, glucose, fructose, lactose, mannitol, xylitol, maltitol, and sorbitol, (b) at least one disintegrant, and (c) at least one lubricant selected from stearic acid, microcrystalline cellulose and combinations thereof; wherein each ingredient in said excipient mixture is present in a functionally effective amount; wherein the excipient mixture comprises 10%-50% by weight of said core; and wherein the sodium content of said pharmaceutical composition is below 120 mg per 1200 mg of free ibuprofen. The compositions are intended to have a low total sodium content. |
