Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs

摘要

The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

主权项

1. A preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs, comprising:
dissolving solid sodium hydroxide into water and adding selenium powder and cetyltrimethylammonium bromide to obtain a selenium solution; dissolving sodium borohydride and another solid sodium hydroxide into water in ice bath to obtain a sodium borohydride solution, and instilling the selenium solution into the sodium borohydride solution for reacting under room temperature for about an hour, then reacting at about 90° C. for about half an hour to complete the reaction and to obtain a alkaline solution of sodium selenide; dissolving 2-Dodecen-1-yl-succinic anhydride into tetrahydrofuran and adding into the alkaline solution of sodium selenide to react for about 12 hours, separating impurities by column chromatography and utilizing anhydrous Na2SO4 or MgSO4 to remove water to obtain diselenide after high temperature drying; dissolving the diselenide into tetrahydrofuran with polyethylene glycol polymer having amino group, and adding 1-Ethyl-3(-3-dimethylaminopropyl)carbodiimide or N-Hydroxysuccinimide to react for about 12 hours, separating impurities by column chromatography to obtain diselenide block copolymer after high temperature drying.