发明名称 |
INDOLE CARBOXAMIDES COMPOUNDS USEFUL AS KINASE INHOBITORS |
摘要 |
Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease. |
申请公布号 |
WO2016065226(A1) |
申请公布日期 |
2016.04.28 |
申请号 |
WO2015US57055 |
申请日期 |
2015.10.23 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
AHMAD, SALEEM;TINO, JOSEPH A.;MACOR, JOHN E.;TEBBEN, ANDREW J.;GONG, HUA;LIU, QINGJIE;BATT, DOUGLAS G.;NGU, KHEHYONG;WATTERSON, SCOTT HUNTER;GUO, WEIWEI;BEAUDOIN BERTRAND, MYRA |
分类号 |
C07D403/12;A61K31/4045;A61P29/00;A61P37/00;C07D209/18;C07D401/04;C07D401/06;C07D401/12;C07D403/04;C07D403/10;C07D413/04;C07D417/04;C07D471/04;C07D487/04;C07D487/10 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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