GUANINE CHEMILUMINESCENCE COMPOUND AND APPLICATIONS

摘要

Chemiluminesescence is emitted from a reaction between phenylglyoxal derivatives and guanine. This chemiluminescence can be used in CRET for the detection of one or more analytes of interest. Chemical pathways depicting the chemiluminescent reaction and intermediates produced therein are shown, as are novel nanoparticles for use in the present methods and compositions.

主权项

1. A compound comprising the structure: wherein Rx is either H or nothing and when nothing, the adjoining N is negatively charged, and wherein R1, R2, and R3 are each independently H, linear or branched C1-C6 alkyl, oxy, or C1-C6 alkoxy groups, and wherein the nucleic acid is a natural or artificial deoxyribonucleic acid or ribonucleic acid.