| 摘要 |
PROBLEM TO BE SOLVED: To provide novel chemical compounds characterized as Rho kinase (ROCK) inhibitors, and methods for their therapeutic use.SOLUTION: The present invention provides methods of using 1,4-benzodiazepine-2,5-dione such as compounds represented by the formula in the figure having ROCK inhibitory activity to treat diseases such as cardiovascular disorders, smooth muscle related disorders, granulomatous disorders, acute macrophage-mediated diseases and autoimmune diseases (irritable bowel syndrome, systemic sclerosis, etc.).SELECTED DRAWING: None |
