SCREEN FOR INHIBITORS OF FILOVIRUS AND USES THEREFOR

摘要

The invention provides methods to identify agents useful to prevent, inhibit or treat viral infections, e.g., filovirus infections, as well as compositions having one or more agents to prevent, inhibit or treat viral infection.

主权项

1. A method to identify one or more agents that inhibit Ebola virus infection, comprising:
a) contacting a host cell, one or more agents and recombinant infectious, biologically contained Ebola virus, the genome of which contains a deletion of sequences corresponding to Ebola virus VP30 sequences, which deletion is effective to prevent expression of functional VP30 upon infection of a cell with the recombinant virus; and b) identifying one or more agents that inhibit viral infection without substantially decreasing host cell viability.