发明名称 |
TECHNIQUE FOR PREPARING AMORPHOUS POSACONAZOLE |
摘要 |
A technique for preparing an amorphous posaconazole. Posaconazole is dissolved in a mixed solvent of an alcohol and an ester, is added to an alkane, a cycloalkane, or an arene, and undergoes precipitation so as to separate out jelly-like solids, that is, amorphous posaconazole; the mass/volume ratio between the posaconazole and the mixed solvent (g/mL) is 1:4 to 1:10; the volume ratio between the alcohol and the ester in the mixed solvent is 1:3 to 1:20; the volume ratio between the mixed solvent and alkane or between the mixed solvent and the arene is 1:1 to 1:4. |
申请公布号 |
WO2016061862(A1) |
申请公布日期 |
2016.04.28 |
申请号 |
WO2014CN91350 |
申请日期 |
2014.11.18 |
申请人 |
JIANGSU HANSYN PHARMACEUTICAL CO., LTD |
发明人 |
DING, ZUNLIANG;WANG, XILIN |
分类号 |
C07D405/14;C07D295/135;C07D307/16;C07D405/06;C07D407/14 |
主分类号 |
C07D405/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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