| 发明名称 |
CD138-TARGETED INTERFERON DEMONSTRATES POTENT APOPTOTIC AND ANTI-TUMOR ACTIVITIES |
| 摘要 |
In various embodiments chimeric moieties (constructs) are provided that show significant efficacy against cancers. In certain embodiments the constructs comprise a targeting moiety that specifically binds CD138 attached to an interferon or to a mutant interferon. In certain embodiments, the constructs comprise anti-CD138 antibody attached to an interferon alpha (IFN-α) or to a mutant interferon alpha. |
| 申请公布号 |
US2016115239(A1) |
申请公布日期 |
2016.04.28 |
| 申请号 |
US201314649888 |
申请日期 |
2013.12.05 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
Morrison Sherie L. |
| 分类号 |
C07K16/28;C07K14/56;A61K45/06;A61K38/21;C07K16/30;A61K39/395;C07K14/57;C07K14/565 |
主分类号 |
C07K16/28 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A chimeric construct comprising an interferon attached to an antibody that binds CD138. |
| 地址 |
Oakland CA US |
