| 发明名称 |
Treponema Pallidum Triplet Antigen |
| 摘要 |
A Treponema pallidum triplet antigen construct is disclosed which includes three Treponema pallidum antigens (TP15, TP17, and TP47), as well as a ten amino acid leader sequence (tag 261) and human copper zinc superoxide dismutase (hSOD). This construct is optimized for in vitro diagnosis of syphilis infection. Plasmids containing DNA encoding the triplet antigen, host cells, production methods, detection methods, and kits are also disclosed. |
| 申请公布号 |
US2016115206(A1) |
申请公布日期 |
2016.04.28 |
| 申请号 |
US201514980200 |
申请日期 |
2015.12.28 |
| 申请人 |
Ortho-Clinical Diagnostics, Inc. |
发明人 |
Zheng Jian;Yura Renee;Yang Jianping |
| 分类号 |
C07K14/20;G01N33/571 |
主分类号 |
C07K14/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant plasmid encoding a Treponema pallidum triplet antigen, wherein the plasmid comprises nucleic acid encoding an amino acid sequence selected from the group consisting of SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, and SEQ ID NO:12. |
| 地址 |
Raritan NJ US |
