| 主权项 |
1. A compound of Formula (I) or a stereoisomeric form thereof, wherein R1 is phenyl or 2-pyridinyl, each optionally substituted with one or more substituents each independently selected from the group of halo, C1-4alkyl, mono- or poly-haloC1-4alkyl, —O—C1-4alkyl, —C1-4alkyl-O—C1-4alkyl, mono- or poly-haloC1-4alkyloxy, —C1-4alkyl-OH, C1-4alkylthio, mono- or poly-haloC1-4alkylthio, cyano, C3-7cycloalkyl optionally substituted with trifluoromethyl, and —SF5; or is R2 is selected from wherein R5 and R6 are each independently selected from the group of hydrogen, halo, cyano, C1-4alkyl, —C1-4alkyl-OH, C3-7cycloalkyl, mono- or poly-haloC1-4alkyl, —C1-4alkyl-O—C1-4alkyl, —O—C1-4alkyl, mono- or poly-haloC1-4alkyloxy, 1-acetylazetidin-3-yl, and NR′R″; wherein R′ is selected from hydrogen and C1-4alkyl; R″ is selected from hydrogen and C1-4alkyl; or R′ and R″ together with the Nitrogen atom to which they are attached form a heterocyclic group selected from the group of 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, 1-piperazinyl, and 4-morpholinyl; wherein each of the heterocyclic groups may be optionally substituted with a substituent selected from halo, hydroxyl, C1-4alkyl, mono- or poly-haloC1-4alkyl, and —(CO)C1-4alkyl; R3 is selected from hydrogen and C1-4alkyl; R4 is selected from the group of hydrogen, C1-4alkyl, mono- or poly-haloC1-4alkyl, —C1-4alkyl-O—C1-4alkyl, and —C1-4alkyl-OH; or a N-oxide, or a pharmaceutically acceptable salt or a solvate thereof. |
