发明名称 |
IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT FC REGIONS AND METHODS OF USING THE SAME |
摘要 |
The present invention relates to molecules, particularly polypeptides, more particularly immunoglobins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC. |
申请公布号 |
WO2006088494(A9) |
申请公布日期 |
2016.04.28 |
申请号 |
WO2005US24645 |
申请日期 |
2005.07.12 |
申请人 |
MACROGENICS, INC.;STAVENHAGEN, JEFFREY;VIJH, SUJATA;RANKIN, CHRISTOPHER;GORLATOV, SERGEY;HUANG, LING |
发明人 |
STAVENHAGEN, JEFFREY;VIJH, SUJATA;RANKIN, CHRISTOPHER;GORLATOV, SERGEY;HUANG, LING |
分类号 |
A61K39/395;C07K16/00;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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