发明名称 |
SUBSTITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR TREATING HCV INFECTIONS |
摘要 |
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I;D-M-D (Formula I);useful as antiviral agents. In certain embodiments disclosed herein M is a group —P-A-P— where A is;;Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure. |
申请公布号 |
US2016115157(A1) |
申请公布日期 |
2016.04.28 |
申请号 |
US201514972827 |
申请日期 |
2015.12.17 |
申请人 |
Achillion Pharmaceuticals, Inc |
发明人 |
Wiles Jason Allan;Wang Qiuping;Hashimoto Akihiro;Pais Godwin;Wang Xiangzhu;Gadhachanda Venkat;Phadke Avinash;Deshpande Milind;Chen Dawei |
分类号 |
C07D403/14;C07D403/04;C07F5/02;C07D209/42 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
1. A compound represented by the structure: wherein R1 is a protecting group selected from the group consisting of acetyl, benzoyl, tert-butyloxycarbonyl (Boc), carbobenzyloxy (Cbz), p-methoxybenzylcarbonyl (Moz), 9-fluorenylmethyloxycarbonyl (FMOC), benzyl, p-methoxybenzyl, 3,4-dimethoxybenzyl, and p-methoxyphenyl; and LG1 is halo. |
地址 |
New Haven CT US |