COMPOSITIONS AND METHODS FOR DETECTING AND TREATING GLIOBLASTOMA

摘要

The present invention provides compositions and methods for the diagnosis and treatment of glioblastoma, particularly tumor propagating cells within the glioblastoma.

主权项

1. A panel for determining the molecular profile of a glioblastoma, the panel comprising lysine-specific demethylase 1 (LSD1; SEQ ID NO: 9, 10, 11 or 12), RE1-silencing transcription factor corepressor 2 (RCOR2; SEQ ID NO: 13 or 14), POU class 3 homeobox 2 (POU3F2; SEQ ID NO: 5 or 6), sex determining region Y-box 2 (SOX2; SEQ ID NO: 1 or 2), spalt-like transcription factor 2 (SALL2; SEQ ID NO: 7 or 8), and/or oligodendrocyte transcription factor 2 (OLIG2; SEQ ID NO: 3 or 4) proteins or nucleic acid molecules or capture reagents that bind to such proteins or nucleic acid molecules.