ENZYME AND USES THEREOF

摘要

The present invention relates generally to methods and materials relating to newly characterised enzymes from Pusillimonas noertemannii, or variants thereof, capable degrading poly-γ-D-glutamic acid, for example as is present in the capsule of B. anthracis. Such depolymerases have utility as therapeutics.

主权项

1. A PGDA depolymerase polypeptide having a sequence which is at least about 60%, 70%, 80% or 85% identical to the amino acid sequence provided herein as SEQ ID NO: 2, which comprises a His tag or which is a fusion protein of SEQ ID NO: 2, or a fragment thereof with a heterologous fusion partner.