Integrated Continuous Isolation of Fluid Streams From Sterile Process Vessels

摘要

Provided herein are isolation processes and the associated hardware to allow fluid streams to be isolated from a sterilized system (e.g., a sterile process vessel) that contains a sterile process. The isolation processes described herein allow for continuous removal of fluid streams (e.g., waste streams, liquid containing recombinant therapeutic proteins) from a sterilized system (e.g., a biological manufacturing system), which provides for less manual manipulation of the sterilized system and a decreased risk of contaminating the sterilized system.

主权项

1. A method of inhibiting contamination of a sterilized system, the method comprising
providing a system comprising first vessel, wherein the first vessel comprises a liquid; flowing a first volume of the liquid out of the first vessel and through a volume of sterilizing gas and into a second vessel.