发明名称 |
CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS |
摘要 |
Described are peptide analogs of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have relatively balanced agonist activity at the glucagon-like peptide 1 (GLP-1) receptor and the glucagon (GCG) receptor, and the use of such GLP-1 receptor/GCG receptor co-agonists for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity. |
申请公布号 |
US2016114000(A1) |
申请公布日期 |
2016.04.28 |
申请号 |
US201514920012 |
申请日期 |
2015.10.22 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
Bianchi Elisabetta;Carrington Paul E.;Deng Qiaolin;Nargund Ravi;Orvieto Federica;Palani Anandan;Pessi Antonello;Tucker Thomas Joseph;Wu Chengwei |
分类号 |
A61K38/26;A61K38/28;C07K14/605 |
主分类号 |
A61K38/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Rahway NJ US |