| 发明名称 |
HYDROPHOBICALLY MODIFIED ANTISENSE OLIGONUCLEOTIDES COMPRISING A TRIPLE ALKYL CHAIN |
| 摘要 |
The present invention concerns an oligonucleotide modified by substitution at the 3′ or the 5′ end by a moiety comprising at least three saturated or unsaturated, linear or branched hydrocarbon chains comprising from 2 to 30 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer. |
| 申请公布号 |
US2016113957(A1) |
申请公布日期 |
2016.04.28 |
| 申请号 |
US201414895344 |
申请日期 |
2014.06.05 |
| 申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ;UNIVERSITÉ DE BORDEAUX ;UNIVERSITE D'AIX-MARSEILLE ;INSTITUT JEAN PAOLI & IRENE CALMETTES ;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
BARTHELEMY Philippe;OUMZIL Khalid;GISSOT Arnaud;ROCCHI Palma;ACUNZO Julie |
| 分类号 |
A61K31/713;A61K31/337;A61K45/06;C12N15/113 |
主分类号 |
A61K31/713 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An oligonucleotide modified by substitution at the 3′ or the 5′ end by a moiety comprising at least three saturated or unsaturated, linear or branched hydrocarbon chains comprising from 2 to 30 carbon atoms. |
| 地址 |
Paris FR |
