COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE

摘要

PROBLEM TO BE SOLVED: To provide methods for inhibiting CD28 mediated T cell activation without involving stimulation of the CD28 signal transduction pathway.SOLUTION: Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds CD28 and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual, methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, and methods involving administering a domain antibody to an individual.SELECTED DRAWING: None