Therapeutic Dosing of a Neuregulin or a Subsequence Thereof for Treatment or Prophylaxis of Heart Failure

摘要

The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects.

主权项

1. A method for treating or preventing heart failure in a mammal, said method comprising:
providing a peptide comprising an epidermal growth factor-like (EGF-like) domain; administering a therapeutically effective amount of said peptide to a mammal at an interval of at least 48 hours, wherein said therapeutically effective amount is effective to treat or prevent heart failure in said mammal.