| 主权项 |
1. A method of treating a condition selected from the group consisting of obesity and pulmonary arterial hypertension comprising administering to a subject having obesity and/or pulmonary arterial hypertension a compound of formula (I) in an amount effective to treat obesity and/or pulmonary arterial hypertension, wherein formula (I) is: wherein W is O or NR5; R1 is H, —CH3, —(CH2)2OH, R2 is R3 is —(CH2)5CH3, —(CH2)6CO2H, —(CH2)6CO2CH3, —(CH2)dNHCO-Ph, —(CH2)6CONH-Ph, —(CH2)6CONHCH2-Ph, R4 and R5 are independently H or —CH3; R6 is O or NR9; R7 is H, —CH3, —C(CH3)3, —CH2OH, —(CH2)2OH, —(CH2)2O(CH2)2OH, —(CH2CH2O)3CH3, —(CH2CH2O)2CH2CO2CH3, —(CH2)5CH3, R8 is H, —OH, —CH2OH, —CO2H, —CO2CH2CH3, —CO(CH2)6CH3, —OCH3, —NH2, —SO2NH2, —CONH-Bn or R9 is H or —CH3; R10 is —CH2NH2, —CO2H or —CO2CH3; R11 is —SO2-Ph, —CH2-Ph, —CONH-Ph, —COCH3,and
R12 is —CH3, where X1, X2, X3, X4, X5, X6 and X7 are independently H, halogen, —OH, —CH3, —CF3, —OCH3, —CO2H, —CO2CH3, —CH2CO2H, —CH2CO2CH3, phenyl or —O-Bn; and where a=0-2; b=1-6; c=0-1; d=4-7; and e=0-1; or a pharmaceutically acceptable salt thereof. |
