发明名称 SUSTAINED AND REVERSIBLE ORAL DRUG DELIVERY SYSTEMS
摘要 A composition that achieves sustained oral drug release is provided. The composition includes liposomes, micelles, or polymeric particles, for example, having a hydrophobic core and an amphipathic corona, wherein the core contains a therapeutic, diagnostic, nutraceutical, cosmeceutical or prophylactic agent to be released, and the corona has targeting ligands immobilized to it. In a preferred embodiment the targeting ligands are bisphosphonate molecules, which enable binding to hydroxyapatite present on teeth. The incorporation of short polyethylene glycol (PEG) chains prevents chain entanglement and ionic interactions, minimizes mucus adhesion, increases particle diffusion rates in mucus, and increases the overall stability of particles in saliva. In a preferred embodiment the agent incorporated is a dental bleaching agent and the ligands selectively bind hydroxyapatite.
申请公布号 WO2016064882(A1) 申请公布日期 2016.04.28
申请号 WO2015US56469 申请日期 2015.10.20
申请人 THE CHILDREN'S MEDICAL CENTER CORPORATION 发明人 KOHANE, DANIEL S.;WYLIE, RYAN
分类号 A61K9/127;A61K9/14;A61K9/51;A61K31/00;A61K31/185;A61K47/48 主分类号 A61K9/127
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