| 摘要 |
A family of potent, stable vitamin D-based complexes for therapeutic use in chronic diseases such as cancer, neuro-degenerative diseases, chronic kidney disease and HIV infection is disclosed. They may be made by interaction with de-glycosylated vitamin D-binding protein to form a dimeric complex which can be further stabilized by unsaturated fatty acids to form a trimeric complex which provides improved interaction at cellular level with the vitamin D receptor at the plasma membrane. Effectiveness can be further improved by dissolving or solubilizing the supplement in a suitable solvent. One delivery mechanism for the complexes is to encapsulate them in liposomes, enabling oral administration. |
