发明名称 |
VIRION DISPLAY ARRAY FOR PROFILING FUNCTIONS AND INTERACTIONS OF HUMAN MEMBRANE PROTEINS |
摘要 |
Provided herein are recombinant virion arrays comprising human membrane bound proteins that retain their native conformations and/or interactions, recombinant HSV-1 virions, and methods of use including high-content, high-throughput assays for screening for ligands and/or drugs that bind human membrane bound proteins, diagnostic assays, proteomic assays, and bio-sensor assays. Also provided are recombinant HSV-1 virions comprising an envelope comprising a plurality of heterologous membrane bound proteins that retain their native conformations and/or interactions as well as recombinant HSV-1 bacterial artificial chromosome (BAC) clones encoding heterologous membrane polypeptides. |
申请公布号 |
EP3011061(A2) |
申请公布日期 |
2016.04.27 |
申请号 |
EP20140813591 |
申请日期 |
2014.06.20 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
ZHU, HENG;DESAI, PRASHANT;LI, MIN;HU, SHAOHUI |
分类号 |
C12Q1/70;C12M1/34 |
主分类号 |
C12Q1/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|