| 摘要 |
Disclosed herein is a novel and inventive synthesis of amino-deoxyavermectins, and in particular, the economically significant, anthelminthic macrolide eprinomectin. The synthesis proceeds via reductive amination of an intermediate in which the allylic alcohol of the benzofuran ring is deprotected. Advantageously, the method of the present invention obviates the need for chromatographic purification. Also disclosed is an imine intermediate produced during the said amination step. |
