发明名称 |
COMPOSITIONS AND METHODS FOR NON-INVASIVE DETECTION AND TREATMENT OF HYPOXIC CELLS IN VIVO |
摘要 |
Compositions and methods used in the non-invasive detection and/or treatment of hypoxic tissues in vivo are described. Compositions including microbubbles functionalized with one or more hypoxia targeting agents and one or more therapeutic compounds, methods of preparing the functionalized microbubbles, and methods of using the functionalized microbubbles for diagnostic and/or therapeutic applications are described, including a method for selectively determining the amount of vascular hypoxia occurring in a tissue. |
申请公布号 |
EP2877212(A4) |
申请公布日期 |
2016.04.27 |
申请号 |
EP20130804301 |
申请日期 |
2013.06.14 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS |
发明人 |
KOONCE, NATHAN A.;GRIFFIN, ROBERT |
分类号 |
A61K47/02;A61K39/44;A61K49/06 |
主分类号 |
A61K47/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|