发明名称 |
GLP-1 DERIVATIVES AND USES THEREOF |
摘要 |
The invention relates to a derivative of a GLP-1 analogue, optionally C-terminally extended, which derivative comprises a first and a second protracting moiety in the form of a C20 or C22 diacid radical, a bis-amino branched linker, and a first and a second further linker each comprising an OEG-like linker element; wherein these elements are interconnected via amide bonds and attached to a Lys residue of the GLP-1 analogue. The invention also relates to intermediate products in the form of novel GLP-1 analogues incorporated in the derivatives of the invention, as well pharmaceutical compositions and medical uses of the derivatives. The derivatives have very long half-lives while maintaining a satisfactory potency, which makes them potentially suitable for once-monthly administration. |
申请公布号 |
EP3010546(A1) |
申请公布日期 |
2016.04.27 |
申请号 |
EP20140731951 |
申请日期 |
2014.06.19 |
申请人 |
NOVO NORDISK A/S |
发明人 |
REEDTZ-RUNGE, STEFFEN;SAUERBERG, PER;KOFOED, JACOB;PETTERSSON, INGRID;TORNØE, CHRISTIAN, WENZEL |
分类号 |
A61K47/50 |
主分类号 |
A61K47/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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