METHOD FOR PREDICTION OF CISPLATIN TREATMENT EFFICACY IN MALIGNANT DISEASE

摘要

FIELD: medicine.SUBSTANCE: allelic variants of TPMT gene and MUTYH gene polymorphisms rs1142345 and rs3219484 are determined in a patient; the allelic status of one or both of the above polymorphisms provides predicting the cisplatin treatment efficacy, wherein the favourable prognosis is stated by the presence two polymorphic wild-type alleles rs1142345 of TPMT gene (genotype AA) and/or a combination of polymorphic wild-and mutant-type alleles rs3219484 of MUTYH gene (genotype GA).EFFECT: implementing the invention is expected to identify the variations which can provide a basis to individualise the use of platinum preparations in an anti-tumour therapy.3 cl, 2 tbl