摘要 |
The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the disclosure provides delta toxin and phenol-soluble modulin peptides as well as mutants, fragments, variants or derivatives thereof. The disclosure further provides multivalent oligopeptides, fusion proteins comprising two or more staphylococcal proteins, e.g., DT, PSM, alpha hemolysin, leukocidin, superantigen, or any fragments, variants, derivatives, or mutants thereof fused together as a single polypeptide in any order. |
申请人 |
INTEGRATED BIOTHERAPEUTICS, INC. |
发明人 |
AMAN, MOHAMMAD JAVAD;ADHIKARI, RAJAN PRASAD;SHULENIN, SERGEY;HOLTSBERG, FREDERICK WAYNE;KARAUZUM, HATICE |