OPTIMISED HEAVY CHAIN AND LIGHT CHAIN SIGNAL PEPTIDES FOR THE PRODUCTION OF RECOMBINANT ANTIBODY THERAPEUTICS

摘要

Antibodies of interest comprising a heavy chain signal peptide and/or a light chain signal peptide or combination thereof and compositions are described. The method of determining the signal peptide including creating data set of antibodies signal peptides, clustering, selecting and creating recombinant antibodies for enhanced expression and secretion are described.