RSV-specific binding molecules and means for producing them

摘要

The invention provides antibodies and functional equivalents thereof which are capable of specifically binding RSV, and means and methods for producing them.

主权项

1. An isolated antibody or functional part, derivative or analogue thereof which specifically binds Respiratory Syncytial Virus and which comprises:
a heavy chain CDR1 sequence comprising the sequence GFSFSHYA (SEQ ID NO:73), and a heavy chain CDR2 sequence comprising the sequence ISYDGENT (SEQ ID NO:74), and a heavy chain CDR3 sequence comprising the sequence ARDRIVDDYYYYGMDV (SEQ ID NO:75), and a light chain CDR1 sequence comprising the sequence QDIKKY (SEQ ID NO:76), and a light chain CDR2 sequence comprising the sequence DAS, and a light chain CDR3 sequence comprising the sequence QQYDNLPPLT (SEQ ID NO:77), and wherein the antibody, or functional part, derivative, or analogue thereof comprises a single chain antibody, a single chain variable fragment (scFv), an Fab fragment, or a F(ab')2 fragment, or wherein the antibody, or functional part, derivative, or analogue thereof comprises a chimeric antibody.