| 主权项 |
1. A compound of Formula I:or a pharmaceutically acceptable salt or ester thereof, wherein:
R1 is optionally substituted C1-12 alkyl,wherein, each substituted R1 is substituted with one or more Q1;
each Q1 is independently selected from the group consisting of C1-6 alkyloxy and —OH; R2 is optionally substituted C3-12 cycloalkyl, wherein, each substituted R2 is substituted with one or more Q2; each Q2, independently, is selected from the group consisting of C1-6 alkyl, C1-6 alkyloxy and —OH; R3 is C4-12 cycloalkylalkylene or substituted C4-12 cycloalkylalkylene, wherein each substituted R3 is substituted with one or more Q3; each Q3, independently, is selected from the group consisting of C1-6 alkyl, C1-6 alkyloxy, and —OH; L is selected from the group consisting of —O—, —S—, —S(O)—, and —S(O)2—; Het is an optionally substituted 3-12 membered heterocyclyl or optionally substituted 3-14 membered heteroaryl; wherein, each substituted Het is substituted with one or more Q4; each Q4, independently, is selected from the group consisting of halogen, oxo, oxide, —NO2, —N(═O), —SR40, —S(O)R40, —S(O)2R40, —S(O)2NR40R41, —NR40C(O)R41, —NR40C(O)NR41R42, —NR40S(O)R41, —NR40S(O)2R41, —OP(O)R41R42, —P(O)R41R42, —P(O)OR41R42, —P(O)(OR41)OR42, —C(O)NR41R42, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C6-12 arylalkyl, C6-12 aryl, C1-6 alkyloxy, C2-6 alkenyloxy, C2-6 alkynyloxy, C3-6 cycloalkyloxy, C6-12 aryloxy, 4-12 membered heterocyclyloxy, —C(O)C1-6 alkyl, —C(O)C2-6 alkenyl, —C(O)C2-6 alkynyl, —C(O)C3-6 cycloalkyl, —C(O)C6-12 aryl, —C(O)C6-12 arylalkyl, 3-10 membered heterocyclyl, —OH, —NR41R42, —C(O)OR40, —CN, —N3, —C(═NR43)NR41R42, —C(═NR43)OR40, —NR40C(═NR43)N R41R42, —NR41C(O)OR40, and —OC(O)NR41R42; each R40, R41, and R42, independently is selected from the group consisting of H, C1-12 alkyl, C2-12 alkenyl, C1-12 alkynyl, C3-12 cycloalkyl, C6-14 aryl, 3-12 membered heterocyclyl, 3-18 membered heteroarylalkyl, and C6-18 arylalkyl; or R41 and R42 taken together with the atoms to which they are attached form a 3 to 10 membered heterocyclyl; each R43, independently, is selected from the group consisting of H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 cycloalkyl, C6-14 aryl, 3-12 membered heterocylyl, C6-18 arylalkyl, —CN, —C(O)R44, —CHO and —S(O)2R44; and each R44 individually is C1-12 alkyl. |
