Tetrazole compounds and methods of making and using same

摘要

Described herein are tetrazole compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tetrazole compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

主权项

1. The compounds N-[1-(1H-tetrazol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]-benzenesulfonamide, N-[3-cyclopropyl-2-(1H-tetrazol-5-yl)-phenyl]-benzenesulfonamide, N-[3-methoxy-2-(1H-tetrazol-5-yl)-phenyl]-benzenesulfonamide, N-[3-methyl-2-(1H-tetrazol-5-yl)-phenyl]-benzenesulfonamide, N-[3-bromo-2-(1H-tetrazol-5-yl)-phenyl]-benzenesulfonamide, and pharmaceutically acceptable salts thereof.