| 发明名称 | Process for the preparation of ospemifene | ||
| 摘要 | The present invention is related to the process for the preparation ospemifene or (Z)-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol (I) and to intermediate compounds used in the process.; | ||
| 申请公布号 | US9321712(B2) | 申请公布日期 | 2016.04.26 |
| 申请号 | US201314436706 | 申请日期 | 2013.10.17 |
| 申请人 | FERMION OY | 发明人 | Tois Jan;Pihko Ainoliisa;Grumann Arne |
| 分类号 | C07C41/26;C07C69/24;C07C67/14;C07C67/293;C07C67/297;C07C69/28;C07C69/753;C07C69/76 | 主分类号 | C07C41/26 |
| 代理机构 | Oblon, McClelland, Maier & Neustadt, L.L.P. | 代理人 | Oblon, McClelland, Maier & Neustadt, L.L.P. |
| 主权项 | 1. A process of preparing a compound of formula (I) which process comprises (a) reacting a compound of formula (III) wherein R is a protecting group tolerant to Grignard or other organometallic reagents, with phenylmagnesium halide, thereby obtaining a compound of formula (IV) wherein R is as defined in formula (III), (b) treating the compound of formula (IV) with hydrochloric acid, thereby obtaining a compound of formula (V) wherein R is as defined as in formula (III), and (c) cleaving the ester bond of the compound of formula (V), thereby obtaining the compound of formula (I). | ||
| 地址 | Espoo FI | ||