| 摘要 |
The present invention provides a method for manufacturing an acetal compound having a hydroxyl group in the molecule, which is a raw material for a polyalkylene glycol derivative having an aldehyde group to be used in pharmaceutical uses, in high purity. An acetal compound represented by the formula [1] is manufactured by performing the steps (A) to (D):
wherein n is 0 or 1 provided that R 1 groups may be bonded or may not be bonded to each other when n is 0; R 1 is an alkyl group having 1 or 2 carbon atoms or an alkylene group having 1 or 2 carbon atoms and the R 1 groups may be same or different from each other; and R 2 is an alkylene group having 1 or 6 carbon atoms,
(A): the acetal compound represented by the formula [1] is dissolved in a solvent made from a hydrocarbon having 5 to 8 carbon atoms in an amount 0.1 mass time or more the amount of the formula [1] to obtain a solution thereof; (B): a buffer of pH 6 to 10 is added in an amount 0.5 mass time or more the amount of the formula [1] to the solution obtained in (A) to extract the acetal compound of the formula [1] into the buffer; (C) : at least one extracting solvent selected from the group consisting of chloroform and dichloromethane is added in an amount 0.5 mass time or more the amount of the acetal compound of the formula [1] to the buffer into which the acetal compound has been extracted, thereby extracting the acetal compound of the formula [1] into the extracting solvent to obtain an extraction solution; and (D): the extraction solution obtained in (C) is distilled at 65°C or lower under a reduced pressure of 0.3 kPa or lower. |
