System and apparatus for nanopore sequencing

摘要

A piezoelectric substrate having a nanopore opening that separates two reservoirs of conductive fluid may provide for sensitive biological measurements by allowing control of the size of the nanopore according to piezoelectric stimulation of the substrate. Multiple embodiments are provided of monolithic piezoelectric substrates and nanopores for this purpose as well as a control system for controlling the nanopore dimensions electrically using AC or DC waveforms.

主权项

1. An apparatus for a study of biological molecules comprising:
a piezoelectric substrate positionable between reservoirs of conductive fluid; a nanopore opening in the piezoelectric substrate between the reservoirs; at least one electrode pair applying an electrical field to the piezoelectric substrate to change a dimension of the piezoelectric substrate holding the nanopore; and at least one electrical sensor measuring a change in the electrical environment of the nanopore wherein the at least one electrode pair is electrically insulated from the piezoelectric substrate and from the reservoirs.