Cyclosporine-containing non-irritative nanoemulsion ophthalmic composition

摘要

Provided is an ophthalmic composition containing cyclosporine as an active ingredient and including polyethoxylated castor oil or polyethoxylated hydrogenated castor oil, and a method of preparing the same. Particularly, the ophthalmic composition is prepared as a nanoemulsion having a particle diameter of 100 nm or less simply by mixing and stirring an oil phase and an aqueous phase without using a high speed stirring or shearing machine, so that it is very physiochemically stable and storable for a long time. In addition, the ophthalmic composition causes no irritation to eyes.

主权项

1. A nanoemulsion ophthalmic composition, comprising: 0.01 to 1 wt % of cyclosporine; 0.5 to 9.79 wt % of polyethoxylated castor oil or polyethoxylated hydrogenated castor oil; and 90 to 99.29 wt % of phosphate buffer, wherein the composition does not contain any other type of oil or emulsifier.