Devices, systems, and methods for controlled hydrodissection of vessel walls

摘要

A device and method for intravascular dissection of a body lumen, and particularly a blood vessel wall, is disclosed herein. One aspect of the present technology, for example, is directed toward a tubular elongated member having a lumen therethrough, wherein the elongated member includes a distal region configured to be positioned within a blood vessel wall. The distal region can include an angled distal face having a distal-most edge configured to puncture the vessel wall and a proximal-most edge. The member can include an exit port fluidly coupled to the lumen, and positioned along the distal face between the distal-most edge and the proximal-most edge. A central longitudinal axis of the exit port can be offset from a central longitudinal axis of the elongated member such that the exit port is closer to the distal-most edge than the proximal-most edge.

主权项

1. A method for separating two or more portions of a vessel wall, the method comprising:
intravascularly delivering a dissection assembly to a dissection site adjacent the vessel wall, the dissection assembly including an elongated tubular member having a slanted distal face and an exit port positioned along the distal face, wherein the distal face has a distal-most edge and a proximal-most edge, and wherein a central longitudinal axis of the exit port is offset from a central longitudinal axis of the elongated tubular member such that the exit port is positioned along the distal face closer to the distal-most edge than the proximal-most edge, and wherein the elongated tubular member further includes
a first distance between the central longitudinal axis of the exit port and a longitudinal axis running through the distal most-edge, the first distance being perpendicular to the central longitudinal axis of the exit port and the longitudinal axis of the distal-most edge,a second distance between the central longitudinal axis of the exit port and a longitudinal axis running through the proximal-most edge, the second distance being perpendicular to the central longitudinal axis of the exit port and the longitudinal axis of the proximal-most edge, andwherein the first distance is between about 35% and about 45% of the second distance; and forming an opening in the vessel wall with the elongated tubular member; advancing the exit port through the opening; and separating vessel wall tissue by ejecting fluid through the exit port while a portion of the distal face remains outside of the opening.