Anti-TNF antibodies, compositions, methods and uses

摘要

The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS: 1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.

主权项

1. A method for treating a TNF mediated condition, comprising
(a) contacting a sample from a subject with an isolated anti-TNF antibody having a variable region comprising SEQ ID NO:7 or 8; (b) detecting whether TNF is present in said sample; and, if so, (c) administering an effective amount of an isolated anti-TNF antibody having a variable region comprising SEQ ID NO:7 or 8.