| 发明名称 | Anti-RSV G protein antibodies | ||
| 摘要 | Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections. | ||
| 申请公布号 | US9321830(B2) | 申请公布日期 | 2016.04.26 |
| 申请号 | US201213626852 | 申请日期 | 2012.09.25 |
| 申请人 | Trellis RSV Holdings, Inc. | 发明人 | Kauvar Lawrence M.;Collarini Ellen J.;Keyt Bruce;Foord Orit |
| 分类号 | A61K39/42;C07K16/10;A61K39/00 | 主分类号 | A61K39/42 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. An isolated monoclonal antibody (mAb) which is 3D3 or 2B11 wherein the light chain variable region (VL) has the amino acid sequence SEQ ID NO:45 and the heavy chain variable region (VH) has the amino acid sequence SEQ ID NO:31 (3D3) or the VL has the amino acid sequence SEQ ID NO:47, and the VH has the amino acid sequence SEQ ID NO:33 (2B11) each VL coupled to human kappa or lambda constant region and each VH coupled to human IgG1 constant region, or an immunoreactive fragment thereof which is a single chain form. | ||
| 地址 | South San Francisco CA US | ||