Compositions and methods for inhibiting norovirus infection

摘要

A composition for use in inhibiting the binding of a Norovirus to the histo-blood group antigen on the surface of epithelia is disclosed. The composition may contain a therapeutically effective amount of a binding-inhibiting compound and a carrier and/or excipient. The compounds may competitively bind a Norovirus that has the capability of binding with the histo-blood group antigens of secretor blood type, including A, B, AB, and O blood types. The compositions may be administered to a human prior to or after infection by a Norovirus, to prevent, ameliorate, or reduce the effects of an infection.

主权项

1. A method for the inhibition of norovirus in a subject in need thereof, comprising the step of administering to the subject a therapeutically effective amount of a compound that inhibits binding of at least one Norovirus to a native histo blood group antigen of the subject, wherein said compound comprises a steroid structure and is selected from the group consisting ofor a pharmaceutically acceptable salt thereof,or a pharmaceutically acceptable salt thereof,or a pharmaceutically acceptable salt thereof,or a pharmaceutically acceptable salt thereof, andor a pharmaceutically acceptable salt thereof,and at least one diluent, carrier and or excipient.