Buprenorphine dimer and its use in treatment of gastrointestinal disorders

摘要

The present invention provides a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, wherein the spacer is bonded to the two opioid molecules via an ether bond. Pharmaceutical compositions comprising such a buprenorphine dimer drug are also disclosed, and the use of such compounds in the treatment of gastrointestinal hyperalgesia generally and in particular diarrhea-predominant irritable bowel syndrome.

主权项

1. A buprenorphine dimer compound having Formula (I):or a pharmaceutically acceptable salt or solvate thereof.