Microfluidic ultrasonic particle separators with engineered node locations and geometries

摘要

An ultrasonic microfluidic system includes a separation channel for conveying a sample fluid containing small particles and large particles, flowing substantially parallel, adjacent to a recovery fluid, with which it is in contact. An acoustic transducer produces an ultrasound standing wave, that generates a pressure field having at least one node of minimum pressure amplitude. An acoustic extension structure is located proximate to said separation channel for positioning said acoustic node off center in said acoustic area and concentrating the large particles in said recovery fluid stream.

主权项

1. An ultrasonic microfluidic apparatus for separating small particles from large particles contained in a sample fluid, comprising:
a sample input channel for channeling the sample fluid containing the small particles and the large particles; a recovery fluid input channel containing recovery fluid, routing said recovery fluid to flow substantially parallel and adjacent to the sample fluid, wherein said recovery fluid contacts the sample fluid; an acoustic transducer that produces an acoustic standing wave, that generates a pressure field having at least one node of minimum sound pressure amplitude; and an acoustic extension structure located proximate the sample fluid and said recovery fluid that positions said at least one acoustic node in said recovery fluid concentrating the large particles in said recovery fluid wherein said acoustic extension structure includes a gel located proximate the sample fluid and said recovery fluid positioning said at least one acoustic node in said recovery fluid concentrating the large particles in said recovery fluid.